The Holy See is realizing a number of humanitarian projects in Ukraine, in particular, through the Catholic Relief Services (“Caritas Internationalis”) and its Ukrainian branch, “Caritas Ukraine”. 

In 2020, the Catholic Foundation "Aid to the Church in Need", through religious centers in Ukraine, carried out humanitarian projects for a total of 165,400 euros.

In 2016-2018 the humanitarian initiative of Pope Francis "Pope for Ukraine" was carried out one of the largest humanitarian projects of the Catholic Church. The total budget for the aid was 16 million euros, 5 million euros of which were allocated from the pontiff's personal fund. More than 900,000 Ukrainians became beneficiaries of humanitarian aid.

In June 2020, Pope Francis transmitted two ventilators to the Ministry of Health of Ukraine.

In February 2021, in the frame of Vatican's humanitarian projects the Mariupol Territorial Medical Association for Child and Women's Health received new medical equipment as part of the.